Preparation of a "Chemical Vaccine" Against Tumor Progression

Preparation of a "chemical vaccine" against tumor progression.

A synthetic antigen containing the presumed receptor site for wheat-germ agglutinin (a lectin capable of specifically agglutinating tumor cells) elicits an immune response in mice capable of cross-reacting with receptor sites for wheat-germ agglutinin on tumor-cell surfaces. Mice immunized against the antigen in complete Freund's adjuvant are able to reject five times as many transplanted myelo...

Use of Sodium Alginate Adjuvant in Preparation of a Formalin Killed Vaccine Against Infectious Bovine Rhinotracheitis

Preparation and in vivo anti-tumor evaluation of human papillomavirus E7 adjuvanted with Montanide ISA 266 as a vaccine candidate

Introduction: Human papillomavirus (HPV) 16 E7 protein is expressed constitutively by HPV-infected tumor cells. Mutant versions of E7 are considered as safer candidates for immunotherapy of cervical cancer.  Different strategies including formulation with adjuvants are used to induce a potent immune response against antigenic proteins. Methods: In this experimental study, we used Escherichia co...

Preparation of concentrated blackleg vaccine

  Blackleg in cattle has been recognized since 1938 in Iran that mostly affects cattle in enzootic farm. Main object of this study was to prepare and formulate a concentrated potent vaccine for immunization of cattle against blackleg in Iran. Experimental concentrated blackleg vaccine was prepared according to the method described by FAO. The medium (Modified medium for production of experiment...

An immunotherapeutic intervention against tumor progression

Targeting the epithelial-to-mesenchymal transition (EMT) is emerging as a novel intervention against tumor progression and metastatic dissemination, as well as the resistance to chemo- and radiotherapy displayed by multiple carcinomas. We have recently developed an immunotherapeutic approach to target a major driver of EMT, the T-box transcription factor T (also known as brachyury). This therap...